A road trip to one of the biggest college football games of the year takes a turn for the worse for Carly (Elisha Cuthbert), Paige (Paris Hilton) and their friends when they decide to camp out for the night before heading to the game. A confrontation with a mysterious trucker at the camp site leaves everyone unsettled, and Carly has her hands full trying to keep the peace between her boyfriend Wade and her hot-headed brother Nick.
They wake up the next morning to find that their car might have been deliberately tampered with. At the risk of being stranded, they accept a local's invitation for a ride into Ambrose, the only town for miles. Once there, they are drawn to Ambrose's main attraction – Trudy's House of Wax, which is filled with remarkably life-like wax sculptures.
But as they soon discover, there is a shocking reason the exhibits look so real. As the friends uncover the town's dark secrets, they are stalked by a mysterious killer and find themselves in a bloody battle for survival. The group must find a way out of Ambrose – or become permanent additions to the House Of Wax.
カーリーと親友のペイジら６人の若者たちは、大学フットボールの試合を観戦するため長距離ドライブでスタジアムへと向かっていた。途中、キャンプ場で一泊した彼らは、翌朝何者かの悪質な悪戯で車の一台が故障してしまったことを知る。
仕方なく仲間と別れ、修理品の調達で近くにある片田舎の町へ向かうカーリーとウェイド。アンブローズというその町は人影もなく、異様なほど静まりかえっていた。
ところが、これといって興味を惹くものがないその町に、なぜか立派な蝋人形館が。そして中には、本物と見まがうばかりに生々しい蝋人形の数々。しかしその人形には恐るべき秘密が隠されていた…。
